Full name: homeobox D10

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: Hox-4.5; Hox-5.3

Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including limb morphogenesis; neuron differentiation; and regionalization. Predicted to be located in cytoplasmic ribonucleoprotein granule; cytosol; and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and limb bud. Human ortholog(s) of this gene implicated in congenital vertical talus. Orthologous to human HOXD10 (homeobox D10). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Biased expression in limb E14.5 (RPKM 13.3), subcutaneous fat pad adult (RPKM 8.3) and 6 other tissues

Gene size: 10834bp

Exon count: 3