Full name: CDC42 effector protein 5

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: Borg3; CEP5

Summary: Cell division control protein 42 (CDC42), a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg (binder of Rho GTPases) family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to CDC42 and regulate its function negatively. The encoded protein may inhibit c-Jun N-terminal kinase (JNK) independently of CDC42 binding. The protein may also play a role in septin organization and inducing pseudopodia formation in fibroblasts [provided by RefSeq, Jul 2013]

Expression: Biased expression in colon (RPKM 54.5), prostate (RPKM 21.2) and 11 other tissues

Gene size: 8271bp

Exon count: 3