Full name: NLR family pyrin domain containing 4

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: CLR19.5; CT58; NALP4; PAN2; PYPAF4; RNH2

Summary: The protein encoded by this gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). This gene product has a demonstrated role as a negative regulator of autophagy and type I interferon signaling pathways as a result of protein interactions with its NACHT domain. The PYD domain has also been shown to be important in the inhibition of NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells). [provided by RefSeq, Dec 2016]

Expression: Biased expression in testis (RPKM 3.5), lymph node (RPKM 0.8) and 1 other tissue

Gene size: 45316bp

Exon count: 10