Full name: glutamate dehydrogenase 1

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: Gdh-X; Glud; Gludl

Summary: Enables glutamate dehydrogenase (NAD+) activity. Involved in glutamine metabolic process and tricarboxylic acid metabolic process. Acts upstream of or within positive regulation of insulin secretion. Located in mitochondrial matrix. Is expressed in several structures, including alimentary system; central nervous system; metanephros; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 6; hyperinsulinism; hypoglycemia; and late onset Parkinson's disease. Orthologous to several human genes including GLUD1 (glutamate dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Ubiquitous expression in liver adult (RPKM 291.2), liver E18 (RPKM 185.4) and 27 other tissues

Gene size: 34307bp

Exon count: 13