Full name: growth differentiation factor 9

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: Gdf-9

Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates ovarian function. Female mice that are homozygous null for this gene are sterile with impaired folliculogenesis. [provided by RefSeq, Jul 2016]

Expression: Biased expression in ovary adult (RPKM 37.3) and testis adult (RPKM 3.0)

Gene size: 6959bp

Exon count: 4