Full name: growth differentiation factor 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: Gdf-1

Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. This protein is translated from a monocistronic mRNA early in development, and from a bicistronic mRNA in later stages that also encodes ceramide synthase 1. [provided by RefSeq, Jul 2016]

Expression: Biased expression in frontal lobe adult (RPKM 27.2), cortex adult (RPKM 24.4) and 11 other tissues

Gene size: 15818bp

Exon count: 8