Full name: laccase domain containing 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: C13orf31; FAMIN; JUVAR

Summary: This gene encodes an oxidoreductase that promotes fatty-acid oxidation, with concomitant inflammasome activation, mitochondrial and NADPH-oxidase-dependent reactive oxygen species production, and bactericidal activity of macrophages. The encoded protein forms a complex with fatty acid synthase on peroxisomes and is thought to be modulated by peroxisome proliferator-activated receptor signaling events. Naturally occurring mutations in this gene are associated with inflammatory bowel disease, Behcet's disease, leprosy, ulcerative colitis, early-onset Crohn's disease, and systemic juvenile idiopathic arthritis. [provided by RefSeq, Apr 2017]

Expression: Ubiquitous expression in testis (RPKM 5.5), small intestine (RPKM 5.3) and 25 other tissues

Gene size: 14755bp

Exon count: 9