Full name: GATA binding protein 3

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: Gata-3; jal

Summary: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; identical protein binding activity; and interleukin-2 receptor binding activity. Involved in several processes, including animal organ development; intracellular signal transduction; and negative regulation of signal transduction. Acts upstream of or within several processes, including animal organ development; regulation of gene expression; and regulation of histone modification. Located in nucleus. Is expressed in several structures, including branchial arch; early conceptus; genitourinary system; nervous system; and sensory organ. Used to study hypoparathyroidism-deafness-renal disease syndrome. Human ortholog(s) of this gene implicated in hypoparathyroidism; hypoparathyroidism-deafness-renal disease syndrome; nephrosis; and sensorineural hearing loss. Orthologous to human GATA3 (GATA binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Biased expression in bladder adult (RPKM 23.1), mammary gland adult (RPKM 22.0) and 12 other tissues

Gene size: 30874bp

Exon count: 8