Full name: GATA binding protein 2

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: Gata-2

Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Acts upstream of or within several processes, including animal organ development; regulation of myeloid cell differentiation; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia; immunodeficiency 21; mental depression; myelodysplastic syndrome; and myeloid leukemia. Orthologous to human GATA2 (GATA binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Biased expression in lung adult (RPKM 56.2), adrenal adult (RPKM 25.3) and 12 other tissues

Gene size: 13142bp

Exon count: 7