Gabra1 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1 [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 14394)
Source: NCBI Gene (ID 14394)
Symbol: Gabra1
Full name: gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Also known as: GABAA-alpha1; GABAAR-alpha1; Gabra-1
Summary: Enables transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Contributes to GABA-gated chloride ion channel activity. Involved in inhibitory synapse assembly and regulation of postsynaptic membrane potential. Located in GABA-ergic synapse and plasma membrane. Is expressed in alimentary system; central nervous system; and eye. Used to study idiopathic generalized epilepsy. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 19 and idiopathic generalized epilepsy 13. Orthologous to human GABRA1 (gamma-aminobutyric acid type A receptor subunit alpha1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 48.5), cortex adult (RPKM 36.1) and 2 other tissues
Orthologs: human
Gene size: 52128bp
Exon count: 12