Full name: glucose-6-phosphatase, catalytic

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: G6Pase; G6pc1; G6pt; Glc-6-Pase

Summary: The enzyme encoded by this gene is a multisubunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for glucose-6-phosphate, inorganic phosphate, and glucose. This gene is one of three glucose-6-phosphatase catalytic-subunit-encoding genes in mouse. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). [provided by RefSeq, Sep 2015]

Expression: Biased expression in kidney adult (RPKM 142.5), liver adult (RPKM 58.4) and 1 other tissue

Gene size: 10188bp

Exon count: 5