Full name: poly(ADP-ribose) polymerase 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: ADPRT; ADPRT 1; ADPRT1; ARTD1; PARP; PARP-1; PARS; PPOL; Poly-PARP; pADPRT-1

Summary: This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]

Expression: Ubiquitous expression in lymph node (RPKM 71.4), appendix (RPKM 40.9) and 25 other tissues

Gene size: 47403bp

Exon count: 23