Ttbk2 tau tubulin kinase 2 [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 140810)
Source: NCBI Gene (ID 140810)
Symbol: Ttbk2
Full name: tau tubulin kinase 2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Also known as: 2610507N02Rik; B930008N24Rik; TTK; Ttbk; Ttbk1; mKIAA0847
Summary: Enables protein serine/threonine kinase activity. Involved in cilium assembly; hindbrain development; and smoothened signaling pathway. Acts upstream of or within several processes, including embryonic brain development; nervous system development; and positive regulation of non-motile cilium assembly. Located in centriole; ciliary basal body; and ciliary transition zone. Is expressed in nervous system. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 11. Orthologous to human TTBK2 (tau tubulin kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in testis adult (RPKM 17.3), cerebellum adult (RPKM 7.9) and 15 other tissues
Orthologs: human
Gene size: 117769bp
Exon count: 17