Ercc2 excision repair cross-complementing rodent repair deficiency, complementation group 2 [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 13871)
Source: NCBI Gene (ID 13871)
Symbol: Ercc2
Full name: excision repair cross-complementing rodent repair deficiency, complementation group 2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Also known as: CXPD; Ercc-2; Mhdarco15; RCO015; XPD
Summary: Predicted to enable several functions, including 5'-3' DNA helicase activity; protein C-terminus binding activity; and protein N-terminus binding activity. Acts upstream of or within several processes, including animal organ development; neurogenesis; and nucleic acid metabolic process. Located in nucleus. Is expressed in central nervous system; eye; hair follicle; and liver. Used to study photosensitive trichothiodystrophy and xeroderma pigmentosum group D. Human ortholog(s) of this gene implicated in several diseases, including acoustic neuroma; acquired immunodeficiency syndrome; carcinoma (multiple); hematologic cancer (multiple); and xeroderma pigmentosum (multiple). Orthologous to human ERCC2 (ERCC excision repair 2, TFIIH core complex helicase subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 38.9), ovary adult (RPKM 35.9) and 28 other tissues
Orthologs: human
Gene size: 13678bp
Exon count: 23