Full name: epidermal growth factor receptor pathway substrate 8

Gene type: protein coding

RefSeq status: VALIDATED

Summary: Enables actin binding activity and small GTPase binding activity. Involved in several processes, including Rac protein signal transduction; actin filament organization; and barbed-end actin filament capping. Acts upstream of or within several processes, including actin cytoskeleton reorganization; behavioral response to ethanol; and cellular response to leukemia inhibitory factor. Located in several cellular components, including brush border; ruffle membrane; and stereocilium tip. Part of NMDA selective glutamate receptor complex. Is expressed in several structures, including adrenal gland; alimentary system; bone; brain; and metanephros. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 102. Orthologous to human EPS8 (epidermal growth factor receptor pathway substrate 8). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Broad expression in colon adult (RPKM 16.0), large intestine adult (RPKM 15.7) and 23 other tissues

Gene size: 172153bp

Exon count: 26