Full name: Eph receptor B2

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: Cek5; Drt; ETECK; Erk; Hek5; Nuk; Prkm5; Qek5; Sek3; Tyro5

Summary: This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors consist of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. The encoded receptor preferentially binds membrane-bound ephrin-B ligands and is involved in nervous system and vascular development. This gene is used as a marker of intestinal stem cells. Homozygous knockout mice for this gene exhibit impaired axon guidance and vestibular function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Expression: Broad expression in whole brain E14.5 (RPKM 18.7), CNS E14 (RPKM 13.6) and 18 other tissues

Gene size: 188788bp

Exon count: 17