Full name: ephrin A5

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: AL-1; EFL-5; Ephrin-A5; Epl7; LERK-7; RAGS

Summary: Enables chemorepellent activity; ephrin receptor binding activity; and neurotrophin TRKB receptor binding activity. Involved in several processes, including ephrin receptor signaling pathway; positive regulation of nervous system development; and synaptic membrane adhesion. Acts upstream of or within cellular response to follicle-stimulating hormone stimulus; cellular response to forskolin; and retinal ganglion cell axon guidance. Located in adherens junction; basement membrane; and plasma membrane. Is active in GABA-ergic synapse. Is expressed in several structures, including alimentary system; central nervous system; embryo ectoderm; limb; and sensory organ. Used to study anencephaly. Orthologous to human EFNA5 (ephrin A5). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Broad expression in CNS E11.5 (RPKM 7.2), limb E14.5 (RPKM 6.9) and 21 other tissues

Gene size: 278361bp

Exon count: 6