Full name: sphingosine-1-phosphate receptor 3

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: Edg3; Lpb3; S1p3

Summary: This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for the lysophospholipid sphingosine 1-phosphate. The gene product functions in endothelial cells and is involved in vascular and heart development. The gene product mediates HDL and HDL-associated lysophospholipid-induced vasorelaxation, and it coordinates with other lysophospholipid receptors in the process of angiogenesis. [provided by RefSeq, Jan 2010]

Expression: Broad expression in limb E14.5 (RPKM 30.0), lung adult (RPKM 20.8) and 19 other tissues

Gene size: 14180bp

Exon count: 2