Full name: dynamin 2

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: Dyn2; Udnm; b2b2159Clo

Summary: Predicted to enable several functions, including D2 dopamine receptor binding activity; enzyme binding activity; and protein domain specific binding activity. Involved in synaptic vesicle endocytosis. Acts upstream of or within aorta development; coronary vasculature development; and ventricular septum development. Located in clathrin-coated pit and photoreceptor inner segment. Is expressed in several structures, including alimentary system; central nervous system; sensory organ; skin; and white fat. Used to study centronuclear myopathy; cystic kidney disease; and myopathy. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate B; centronuclear myopathy 1; and lethal congenital contracture syndrome. Orthologous to human DNM2 (dynamin 2). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Ubiquitous expression in duodenum adult (RPKM 68.5), colon adult (RPKM 65.8) and 28 other tissues

Gene size: 82889bp

Exon count: 24