Dnah11 dynein, axonemal, heavy chain 11 [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 13411)
Source: NCBI Gene (ID 13411)
Symbol: Dnah11
Full name: dynein, axonemal, heavy chain 11
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Also known as: Dnahc11; avc4; b2b1203Clo; b2b1279Clo; b2b1289Clo; b2b1727Clo; b2b598Clo; iv; lrd
Summary: Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Acts upstream of or within several processes, including cardiac septum morphogenesis; determination of left/right symmetry; and flagellated sperm motility. Located in 9+0 motile cilium; 9+2 motile cilium; and proximal portion of axoneme. Is expressed in node. Used to study Kartagener syndrome; atrioventricular septal defect; primary ciliary dyskinesia 7; and visceral heterotaxy. Human ortholog(s) of this gene implicated in Kartagener syndrome and primary ciliary dyskinesia 7. Orthologous to human DNAH11 (dynein axonemal heavy chain 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in frontal lobe adult (RPKM 1.1), cerebellum adult (RPKM 1.0) and 20 other tissues
Orthologs: human
Gene size: 321062bp
Exon count: 86