Full name: cytochrome P450, family 1, subfamily b, polypeptide 1

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: CP1B; CYPIB1; P4501b1

Summary: Enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Involved in several processes, including camera-type eye development; cellular response to oxidative stress; and retinoid metabolic process. Acts upstream of or within several processes, including endothelial cell-cell adhesion; toxin metabolic process; and vasculature development. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; musculature; nervous system; and sensory organ. Used to study buphthalmos. Human ortholog(s) of this gene implicated in Peters anomaly; anterior segment dysgenesis 6; breast cancer; glaucoma (multiple); and lung squamous cell carcinoma. Orthologous to human CYP1B1 (cytochrome P450 family 1 subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Biased expression in ovary adult (RPKM 41.8), spleen adult (RPKM 11.1) and 7 other tissues

Gene size: 8122bp

Exon count: 3