Full name: cathepsin C

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: CatC; DPP1; DPPI

Summary: This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the dipeptidyl peptidase 1 light, heavy, and exclusion domain chains, which together comprise one subunit of the homotetrameric enzyme. This enzyme has amino dipeptidase activity and may play a role in the activation of granzymes during inflammation. Homozygous knockout mice for this gene exhibit impaired granzyme activation and enhanced survival in a sepsis model. [provided by RefSeq, Aug 2015]

Expression: Ubiquitous expression in lung adult (RPKM 8.0), mammary gland adult (RPKM 4.8) and 22 other tissues

Gene size: 37850bp

Exon count: 10