Full name: cysteine and glycine-rich protein 3

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: CRP3; MLP; MMLP

Summary: Enables actinin binding activity and telethonin binding activity. A structural constituent of muscle. Involved in several processes, including cardiac muscle contraction; cardiac myofibril assembly; and detection of muscle stretch. Acts upstream of or within several processes, including T-tubule organization; insulin receptor signaling pathway; and protein kinase C signaling. Located in Z disc. Is expressed in several structures, including genitourinary system; heart; limb segment; paraxial mesenchyme; and skeletal musculature. Used to study congestive heart failure; dilated cardiomyopathy 1M; and hypertrophic cardiomyopathy 12. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1M; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 12. Orthologous to human CSRP3 (cysteine and glycine rich protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Restricted expression toward heart adult (RPKM 191.8)

Gene size: 17654bp

Exon count: 7