Full name: v-crk avian sarcoma virus CT10 oncogene homolog-like

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: 1110025F07Rik; Crkol; snoop

Summary: This gene is part of a family of adapter proteins that mediate formation of signal transduction complexes in response to extracellular stimuli, such as growth and differentiation factors. Protein-protein interactions occur through the SH2 domain, which binds phosphorylated tyrosine residues, and the SH3 domain, which binds proline-rich peptide motifs. These interactions promote recruitment and activation of effector proteins to regulate cell migration, adhesion, and proliferation. In certain mouse genetic backgrounds this protein is essential for embryonic development. It is important for neural crest cell differentiation and survival and is proposed to play an important role in transducing the oncogenic signal of Bcr/Abl. Deletion of this gene in mouse mimics the phenotype of DiGeorge/velocardiofacial syndrome in human. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013]

Expression: Ubiquitous expression in thymus adult (RPKM 14.0), whole brain E14.5 (RPKM 13.0) and 28 other tissues

Gene size: 35456bp

Exon count: 3