Full name: chloride channel, voltage-sensitive 2

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: ClC-2; Clc2; nmf240

Summary: Enables voltage-gated chloride channel activity. Acts upstream of or within cell differentiation involved in salivary gland development and retina development in camera-type eye. Predicted to be located in dendrite; perikaryon; and plasma membrane. Predicted to be part of chloride channel complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including central nervous system; gonad; hindlimb phalanx; notochord; and visual system. Used to study leukodystrophy. Human ortholog(s) of this gene implicated in idiopathic generalized epilepsy 11 and primary hyperaldosteronism. Orthologous to human CLCN2 (chloride voltage-gated channel 2). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Broad expression in colon adult (RPKM 62.6), adrenal adult (RPKM 45.6) and 23 other tissues

Gene size: 15312bp

Exon count: 25