Full name: suppressor of cytokine signaling 1

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: Cish1; Cish7; JAB; SOCS-1; SSI-1

Summary: Enables kinase inhibitor activity. Involved in negative regulation of CD8-positive, alpha-beta T cell differentiation and positive regulation of CD4-positive, alpha-beta T cell differentiation. Acts upstream of or within several processes, including cell surface receptor signaling pathway; negative regulation of insulin receptor signaling pathway; and regulation of peptidyl-tyrosine phosphorylation. Predicted to be located in cytoplasmic ribonucleoprotein granule and nucleoplasm. Predicted to be part of phosphatidylinositol 3-kinase complex. Is expressed in several structures, including adipose tissue; gut; hemolymphoid system gland; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in ovarian carcinoma; prostate cancer; and urinary bladder cancer. Orthologous to human SOCS1 (suppressor of cytokine signaling 1). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Biased expression in thymus adult (RPKM 221.8), adrenal adult (RPKM 34.5) and 7 other tissues

Gene size: 1729bp

Exon count: 2