Full name: cyclin-dependent kinase 5

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: Crk6

Summary: Enables several functions, including Hsp90 protein binding activity; acetylcholine receptor activator activity; and signaling receptor binding activity. Involved in regulation of dendritic spine morphogenesis; regulation of glutamatergic synaptic transmission; and regulation of protein localization to plasma membrane. Acts upstream of or within several processes, including chemical synaptic transmission; nervous system development; and regulation of intracellular protein transport. Located in several cellular components, including axon; filopodium; and lamellipodium. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease and lissencephaly 7 with cerebellar hypoplasia. Orthologous to human CDK5 (cyclin dependent kinase 5). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Ubiquitous expression in CNS E18 (RPKM 36.7), CNS E14 (RPKM 31.7) and 28 other tissues

Gene size: 16143bp

Exon count: 13