Full name: mitochondrial ribosomal protein L10

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: L10MT; MRP-L10; MRP-L8; MRPL8; RPML8

Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants that encode two different isoforms. A pseudogene corresponding to this gene is found on chromosome 5q. [provided by RefSeq, Nov 2010]

Expression: Ubiquitous expression in ovary (RPKM 25.7), heart (RPKM 18.3) and 25 other tissues

Gene size: 8270bp

Exon count: 6