Full name: CD2-associated protein

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: METS-1; Mets1

Summary: This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. The mouse genome contains at least two pseudogenes located on chromosomes 9 and 17. [provided by RefSeq, Jul 2008]

Expression: Ubiquitous expression in bladder adult (RPKM 14.9), placenta adult (RPKM 10.1) and 28 other tissues

Gene size: 127739bp

Exon count: 20