Full name: cholecystokinin

Gene type: protein coding

RefSeq status: VALIDATED

Summary: This gene encodes a member of the gastrin/cholecystokinin family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the peptide hormones cholecystokinin-8, -12, -33, and others. The encoded peptides have been shown to regulate gastric acid secretion and food intake. A sulfated form of cholecystokinin-8 may modulate neuronal activity in the brain. Homozygous knockout mice for this gene exhibit impaired insulin secretion, enhanced insulin sensitivity, and resistance to obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]

Expression: Biased expression in cortex adult (RPKM 201.9), frontal lobe adult (RPKM 179.3) and 6 other tissues

Gene size: 5871bp

Exon count: 5