Full name: calsequestrin 2

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: Csq2; ESTM52; cCSQ

Summary: Enables calcium ion binding activity. Involved in regulation of heart rate; regulation of ion transmembrane transport; and sarcomere organization. Acts upstream of or within regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion. Located in Z disc and sarcoplasmic reticulum lumen. Part of junctional membrane complex. Is expressed in several structures, including cardiovascular system; diaphragm; eye; male reproductive system; and upper leg muscle. Used to study catecholaminergic polymorphic ventricular tachycardia 2. Human ortholog(s) of this gene implicated in catecholaminergic polymorphic ventricular tachycardia 2. Orthologous to human CASQ2 (calsequestrin 2). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Biased expression in heart adult (RPKM 170.2), bladder adult (RPKM 15.9) and 1 other tissue

Gene size: 60100bp

Exon count: 12