Full name: caspase 2

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: CASP-2; ICH-1; NEDD-2; Nedd2

Summary: This gene encodes the evolutionarily ancient and most conserved member of the cysteine proteases that plays important role in stress-induced apoptosis, DNA repair and tumor suppression. Mice lacking the encoded protein develop normally but display cell type-specific apoptotic defects. Germ cells and oocytes from such mice were found to be resistant to cell death after treatment with chemotherapeutic drugs. [provided by RefSeq, Apr 2015]

Expression: Ubiquitous expression in thymus adult (RPKM 27.3), limb E14.5 (RPKM 22.2) and 27 other tissues

Gene size: 17602bp

Exon count: 12