Full name: calmodulin 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: CaM; Calm; Cam1

Summary: This gene encodes a member of the EF-hand calcium-binding protein family. The encoded protein acts as a calcium sensor and is involved in relaying signals to calcium-sensitive proteins, enzymes and ion channels. The protein-calcium complex binds target proteins to regulate several cellular processes, including smooth muscle contraction, inflammation, apoptosis and the immune response. Mutations in the human gene are associated with catecholaminergic polymorphic ventricular tachycardia and long QT syndrome 14. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

Expression: Broad expression in cortex adult (RPKM 432.2), frontal lobe adult (RPKM 376.1) and 26 other tissues

Gene size: 10390bp

Exon count: 7