Full name: bone morphogenetic protein receptor, type 1A

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: 1110037I22Rik; ALK-3; ALK3; BMPR-1A; BMPR-IA; Bmpr; SKR5

Summary: Enables BMP binding activity; BMP receptor activity; and enzyme activator activity. Involved in several processes, including circulatory system development; fibrous ring of heart morphogenesis; and positive regulation of cell population proliferation. Acts upstream of or within several processes, including animal organ development; limb morphogenesis; and regionalization. Located in cell surface. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study Ebstein anomaly; Wolff-Parkinson-White syndrome; chromosome 10q23 deletion syndrome; juvenile polyposis syndrome; and osteoarthritis. Human ortholog(s) of this gene implicated in hereditary mixed polyposis syndrome 2; intestinal disease; and juvenile polyposis syndrome. Orthologous to human BMPR1A (bone morphogenetic protein receptor type 1A). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Broad expression in bladder adult (RPKM 18.4), limb E14.5 (RPKM 14.7) and 22 other tissues

Gene size: 92318bp

Exon count: 15