Full name: bone morphogenetic protein 5

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: se

Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Mice with null mutations in this gene exhibit a short ear phenotype, which is characterized by reduced size of the external ear, altered size and shape of the sternum, and other skeletal and soft-tissue abnormalities. [provided by RefSeq, Jul 2016]

Expression: Biased expression in bladder adult (RPKM 8.5), lung adult (RPKM 3.4) and 10 other tissues

Gene size: 124952bp

Exon count: 7