Full name: activating transcription factor 3

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: LRG-21

Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cellular response to amino acid starvation; negative regulation of ERK1 and ERK2 cascade; and regulation of gene expression. Acts upstream of or within gluconeogenesis; negative regulation of transcription, DNA-templated; and skeletal muscle cell differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and limb long bone. Orthologous to human ATF3 (activating transcription factor 3). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Broad expression in small intestine adult (RPKM 10.5), large intestine adult (RPKM 10.2) and 19 other tissues

Gene size: 13038bp

Exon count: 4