Apbb1 amyloid beta (A4) precursor protein-binding, family B, member 1 [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 11785)
Source: NCBI Gene (ID 11785)
Symbol: Apbb1
Full name: amyloid beta (A4) precursor protein-binding, family B, member 1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Also known as: Fe65; Rir
Summary: Enables ubiquitin protein ligase binding activity. Involved in several processes, including double-strand break repair; positive regulation of DNA repair; and smooth muscle contraction. Acts upstream of or within several processes, including generation of neurons; negative regulation of neuron differentiation; and visual learning. Located in cytoplasm and nucleus. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and neuromuscular junction. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human APBB1 (amyloid beta precursor protein binding family B member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in cortex adult (RPKM 63.0), cerebellum adult (RPKM 56.3) and 19 other tissues
Orthologs: human
Gene size: 23480bp
Exon count: 19