Full name: arachidonate 5-lipoxygenase

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: 5-LO; 5-LOX; 5LO; 5LX; F730011J02

Summary: Enables arachidonate 5-lipoxygenase activity. Involved in several processes, including leukocyte migration; negative regulation of angiogenesis; and regulation of cellular response to stress. Acts upstream of or within leukotriene biosynthetic process and leukotriene production involved in inflammatory response. Located in cytoplasm and nucleus. Is expressed in duodenum epithelium and small intestine epithelium. Human ortholog(s) of this gene implicated in artery disease (multiple); asthma (multiple); pancreatic cancer; and pulmonary tuberculosis. Orthologous to human ALOX5 (arachidonate 5-lipoxygenase). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Broad expression in lung adult (RPKM 3.4), heart adult (RPKM 2.7) and 22 other tissues

Gene size: 51110bp

Exon count: 15