Adamts1 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 11504)
Source: NCBI Gene (ID 11504)
Symbol: Adamts1
Full name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Also known as: ADAM-TS1; ADAMTS; ADAMTS-1; C3-C5; METH-1; METH1
Summary: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family and preproprotein that is proteolytically processed to generate a mature protein product. This secreted protein product plays an important role in ovulation, likely through its cleavage of the extracellular matrix component versican. The encoded protein may enhance tumorigenesis in a mouse model of breast cancer. Homozygous knockout mice for this gene exhibit enhanced perinatal lethality, impaired growth and adipose tissue development, and impaired ovulation in females. [provided by RefSeq, Oct 2015]
Expression: Broad expression in lung adult (RPKM 22.1), subcutaneous fat pad adult (RPKM 15.6) and 23 other tissues
Orthologs: human
Gene size: 9287bp
Exon count: 9