Full name: SLAM family member 6

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: CD352; KALI; KALIb; Ly108; NTB-A; NTBA; SF2000

Summary: The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]

Expression: Biased expression in lymph node (RPKM 29.2), spleen (RPKM 15.5) and 7 other tissues

Gene size: 38220bp

Exon count: 9