Full name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 1

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: CD143

Summary: Enables metallopeptidase activity and peptidyl-dipeptidase activity. Involved in several processes, including cell proliferation in bone marrow; positive regulation of protein modification process; and regulation of gene expression. Acts upstream of or within several processes, including heart contraction; neutrophil mediated immunity; and positive regulation of systemic arterial blood pressure. Located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); heart valve disease (multiple); and lung disease (multiple). Orthologous to human ACE (angiotensin I converting enzyme). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Biased expression in lung adult (RPKM 304.6), duodenum adult (RPKM 225.6) and 6 other tissues

Gene size: 22017bp

Exon count: 26