Full name: monoglyceride lipase

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: HU-K5; HUK5; MAGL; MGL

Summary: This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

Expression: Broad expression in fat (RPKM 103.8), esophagus (RPKM 51.9) and 19 other tissues

Gene size: 134120bp

Exon count: 12