Full name: Ras association domain family member 8

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: C12orf2; HOJ1

Summary: This gene encodes a member of the Ras-assocation domain family (RASSF) of tumor suppressor proteins. This gene is essential for maintaining adherens junction function in epithelial cells and has a role in epithelial cell migration. It is a lung tumor suppressor gene candidate. A chromosomal translocation t(12;22)(p11.2;q13.3) leading to the fusion of this gene and the FBLN1 gene is found in a complex type of synpolydactyly. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

Expression: Broad expression in testis (RPKM 13.9), endometrium (RPKM 13.0) and 23 other tissues

Gene size: 121658bp

Exon count: 15