Full name: SPT16 homolog, facilitates chromatin remodeling subunit

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: CDC68; FACTP140; NEDDFAC; SPT16; SPT16/CDC68

Summary: Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009]

Expression: Ubiquitous expression in testis (RPKM 30.8), lymph node (RPKM 27.6) and 25 other tissues

Gene size: 32544bp

Exon count: 27