Full name: adenylate cyclase 5

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: AC5; DSKOD; FDFM

Summary: This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

Expression: Broad expression in heart (RPKM 22.9), brain (RPKM 7.3) and 17 other tissues

Gene size: 166795bp

Exon count: 32