Full name: receptor interacting serine/threonine kinase 3

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: RIP3

Summary: The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]

Expression: Broad expression in small intestine (RPKM 12.2), duodenum (RPKM 10.4) and 21 other tissues

Gene size: 3967bp

Exon count: 10