Bcr BCR activator of RhoGEF and GTPase [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 110279)
Source: NCBI Gene (ID 110279)
Symbol: Bcr
Full name: BCR activator of RhoGEF and GTPase
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Also known as: 5133400C09Rik; mKIAA3017
Summary: Enables GTPase activator activity. Involved in several processes, including negative regulation of blood vessel remodeling; negative regulation of cellular extravasation; and regulation of vascular permeability. Acts upstream of or within several processes, including animal organ development; cellular response to lipopolysaccharide; and regulation of vesicle-mediated transport. Located in cytosol; plasma membrane; and postsynaptic density. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including cardiovascular system; central nervous system; forelimb bud; genitourinary system; and spleen. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; chronic myeloid leukemia; and leukemia. Orthologous to human BCR (BCR activator of RhoGEF and GTPase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 14.4), lung adult (RPKM 12.9) and 28 other tissues
Orthologs: human
Gene size: 124372bp
Exon count: 25