Full name: Braf transforming gene

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: 9930012E13Rik; B-raf; Braf-2; Braf2; C230098H17; D6Ertd631e

Summary: Enables protein kinase activity. Involved in protein phosphorylation. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; negative regulation of apoptotic process; and positive regulation of cellular component organization. Located in several cellular components, including cell body; mitochondrion; and neuron projection. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study Langerhans-cell histiocytosis; cardiofaciocutaneous syndrome; melanoma; and thyroid gland papillary carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 7; carcinoma (multiple); cardiofaciocutaneous syndrome (multiple); central nervous system benign neoplasm (multiple); and melanoma (multiple). Orthologous to human BRAF (B-Raf proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Ubiquitous expression in frontal lobe adult (RPKM 6.7), bladder adult (RPKM 6.5) and 25 other tissues

Gene size: 122422bp

Exon count: 21