Full name: selenoprotein S

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: 1500011E07Rik; H-4; H-47; H4; H47; Sels; Seps1; Vimp

Summary: This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion (PMID:23614019). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2017]

Expression: Ubiquitous expression in placenta adult (RPKM 73.8), testis adult (RPKM 50.8) and 28 other tissues

Gene size: 9757bp

Exon count: 6