FERMT2 FERM domain containing kindlin 2 [ Homo sapiens (human) ]
Source: NCBI Gene (ID 10979)
Source: NCBI Gene (ID 10979)
Symbol: FERMT2
Full name: FERM domain containing kindlin 2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Also known as: KIND2; MIG2; PLEKHC1; UNC112; UNC112B; mig-2
Summary: Enables several functions, including actin binding activity; phosphatidylinositol-3,4,5-trisphosphate binding activity; and type I transforming growth factor beta receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of cell differentiation; and positive regulation of cellular component biogenesis. Acts upstream of or within cell adhesion and protein localization to cell junction. Located in cytosol; focal adhesion; and nucleoplasm. Is extrinsic component of cytoplasmic side of plasma membrane. Part of adherens junction and plasma membrane. Biomarker of acute myeloid leukemia. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in fat (RPKM 84.8), endometrium (RPKM 56.1) and 22 other tissues
Orthologs: mouse
Gene size: 93778bp
Exon count: 18